How Curcumin In Turmeric Kills Cancer Cells
Curcumin is the yellow pigment in turmeric.
Based on chemopreventive agents mode or mechanism of action, curcumin is classified into the antiproliferative, antioxidant and carcinogen-blocking agent subgroups.
There are multiple biochemical mechanisms involved in regulating “programmed cell death”, which curcumin’s anticancer effect plays a role in.
The human body is estimated to consist or 10 to 13 trillion cells. Almost all of which die and are replaced about every 100 days.
Each day then 100 to 130 billion cells die due to apoptosis or the process of programmed cell death.
However, cancer cells don’t die. They seem to turn off their suicide gene.
Curcumin reprograms the self-destruct mechanism in cancer cells.
One pathway for curcumin-induced apoptosis is Fas, DR5, DR4, FADD, Caspase-8… upregulation of death receptor 5 (DR5) demonstrated in kidney cancer cells, skin cancer, nose and throat cancer.
More directly, curcumin activates the death machine caspase or executioner enzyme which destroys cancer cells from within by chopping up proteins as in lung cancer and colon cancer.
Curcumin activates many more apoptotic and inhibitory pathways in tumor cells.
Curcumin tends to leave normal cells alone but the mechanism is not understood.
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